The hotel offers several types of rooms. They have Queen Rooms with Accessible Tub and Queen Rooms with Roll-in-Shower, both of which are accessible and non-smoking. These rooms accommodate 2 adults and 1 child and have a queen-size bed. The hotel also has Double Rooms with Two Double Beds and King Rooms, both non-smoking. The Double Rooms accommodate 4 adults and 3 children with two double beds, while the King Rooms accommodate 2 adults and 1 child with a king-size bed. They also have a Queen Room on the first floor, which is accessible and non-smoking with a queen-size bed.

Guests at Sleep Inn Wytheville I-77 and I-81 can spend their time enjoying the leisure amenities available at the hotel. They can visit the fitness center to maintain their fitness routine during their stay. Additionally, guests can make use of the business center for any work-related needs.

When it comes to dining, the hotel offers the Sagebrush restaurant. This steakhouse provides a family-friendly ambiance for guests to enjoy a delicious meal without having to leave the premises. It offers a variety of steak options and is a convenient choice for guests looking for a satisfying dining experience.

Overall, guests at Sleep Inn Wytheville I-77 and I-81 can make the most of their time by engaging in leisure activities like using the fitness center and enjoying a meal at the hotel's on-site restaurant, Sagebrush.