The Holiday Inn Express and Suites Sikeston offers a variety of room types. These include the King Leisure - Non Smoking room with 1 King size bed, the Queen Room with Two Queen Beds - Non-Smoking room with 2 Queen size beds, the Queen Suite - Non-Smoking room with 1 Queen size bed, the Queen Room with Two Queen Beds - Mobility Access with Bath Tub, the Queen Room with Two Queen Beds - Hearing Accessible with Roll-In Shower, the Queen Room with Two Queen Beds - Disability Access / Non-Smoking, the King Room - Disability Access Tub/ Non-Smoking with 1 King size bed, the Standard King Room - Communication Accessible with 1 King size bed, and the King Suite - Non-Smoking with 1 King size bed. All rooms are non-smoking and vary in occupancy, accommodating 2 adults and 1 child, up to 7 adults and 4 children.

At Holiday Inn Express and Suites Sikeston, guests can enjoy their time at the hotel by taking advantage of the leisure amenities available. One of the highlights is the indoor swimming pool, which is available all season long. This allows guests to enjoy swimming regardless of the weather outside. The pool is also a saltwater pool, providing a unique and refreshing swimming experience.

In addition to the swimming pool, guests can also make use of the fitness center, allowing them to maintain their exercise routine during their stay. For those who need to attend to business matters, there is a business center available as well.

Overall, guests at Holiday Inn Express and Suites Sikeston have the opportunity to relax and unwind with the indoor swimming pool, stay active at the fitness center, and take care of any work-related tasks at the business center.

The Holiday Inn Express and Suites Sikeston has an indoor pool available for guests. The pool is open year-round and features a saltwater system. However, there is an age restriction, limiting access to adults only.