S Hotel Boutique Thessaloniki is a 5-star hotel located at Kalapothaki 5 in Thessaloníki, Greece, just 0,8 mi from the city center. Minimum price starts from $153 per night. The property has 2,952 reviews, signaling strong traveler interest.

Guest facilities include free Wi-Fi, air conditioning, soundproof rooms, a terrace and balcony, a 24-hour front desk, and non-smoking rooms. Dining and services feature a restaurant and bar, room service, and a tour desk, while practical extras cover pet-friendly policy (extra charges), babysitting/child services (extra charges), and business and private parking (both extra charges). Shuttle options—airport shuttle and other shuttle services—are available for an additional fee.

Accessibility and views are highlighted by wheelchair accessibility, an elevator with access to upper floors, and the option of a landmark view as well as general views. The room amenity set includes free toiletries, and the property offers a kid-friendly buffet.

Sigma, the on-site Mediterranean restaurant, invites guests to dine in a setting that can feel family-friendly, traditional, modern, or romantic. The menu pairs well with a relaxed terrace or balcony moment, perfect for winding down after a day of sightseeing. The dining option adds a versatile vibe to the stay, whether a casual lunch or a special evening out.

Accommodations span a diverse range, from King and Queen rooms to more spacious suites. The lineup includes options such as Deluxe King, Junior Suite, and Penthouse Suite (538 sqft) with a Queen bed plus two sofa beds. Some layouts come with balconies, like Queen Room, Balcony (269 sqft) and King Room, Balcony (323 sqft), offering sunny spots to enjoy the backdrop of Thessaloniki.

Pets are welcome on request, with charges possibly applying. Non-smoking rooms are available, and private or business parking can be arranged for an additional fee, catering to both leisurely getaways and longer stays.