The Residence Inn Frederick offers a variety of rooms including One-Bedroom Queen Suites with Sofa Beds, Queen Studios with Sofa Beds, and 2 Bedroom Suites. Smoking is not allowed in any of these rooms. The rooms can accommodate between 4 to 6 adults, with additional capacity for children. The bed sizes range from king size beds to queen size beds, with some rooms also offering sofa beds.

At Residence Inn Frederick, guests can spend their time enjoying a range of leisure amenities. The hotel offers a hot tub/Jacuzzi, perfect for relaxation and unwinding after a long day. For fitness enthusiasts, there is a well-equipped fitness center, allowing guests to maintain their exercise routines while away from home. The hotel also provides a business center, catering to the needs of business travelers who may require access to printing, copying or faxing services. Furthermore, the presence of a barbecue facility offers guests the opportunity to indulge in outdoor cooking and dining experiences during their stay. Additionally, the hotel offers board games and puzzles, providing entertainment options for those who prefer indoor recreational activities. Whether it's relaxing in the hot tub, staying active in the fitness center, taking care of business needs, enjoying a barbecue or playing board games, Residence Inn Frederick offers a variety of options for guests to make the most of their time at the hotel.